ceesdekker No Further a Mystery
ceesdekker No Further a Mystery
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Nanotechnology offers a range of options to lead to biology. Listed here I'll current illustrations wherever nanofabrication – the ability to make confined structures with dimensions at will – is utilized to examine the biophysics of single molecules and cells. I will present some illustrations from our lab:
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Dynamics of initiation, termination and reinitiation of DNA translocation from the motor protein EcoR124I
Due to the fact 2000, Dekker has shifted the principle focus of his do the job in direction of biophysics exactly where he research the properties of single biomolecules and cells using the instruments of nanotechnology. This modification of area was pushed by his fascination with the remarkable performing of biological molecular constructions, together with with the lengthy-term point of view a large number of fascinating discoveries might be anticipated With this industry.[five] Current lines of study in his biophysics group are while in the parts of:[six]
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Case in point (3) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim with the pore is highlighted in red, plus a 3D rendering of your motion with the DNA rod is displayed.
Length Charge of personal carbon nanotubes by nanostructuring Using the scanning tunneling microscope
Studying DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
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one). The existing–voltage curves showed considerable modulations with gate voltage, even at place temperature, which was consistent with band bending within a ~0.six eV bandgap semiconducting nanotube. These data also showed the conductance may very well be modulated by 6 orders of magnitude by altering the gate voltage. The outcome of the do the job — a room-temperature transistor made out of one carbon nanotube molecule — were being published in Nature in May possibly 1998.
[fourteen] In 2005 Dekker turned linked to Netherlands-huge conversations about Clever Design and style, a motion that he has considering the fact that Obviously distanced himself from. Dekker advocates that science and faith are usually not in opposition but could be harmonized.
Cees Dekker is Distinguished College Professor at TU Delft. Skilled as being a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes while in the nineties. Considering that 2000, he moved to one-molecule biophysics and nanobiology. His latest research concentrates on (i) nanopores for protein sequencing; (ii) chromosome composition, especially SMC motor protein; and (iii) developing a residing artificial cell from lifeless molecules. Dekker is surely an elected member from the KNAW and fellow towards the APS and also the IOP.
2008, first observation of protein-coated DNA translocation via nanopores; resolved the origin of the electrophoretic force on DNA in nanopores; ceesdekker.net discovered a significant velocity increase of microtubules in electric powered fields; found out an anomalous electro-hydrodynamic orientation of microtubules; and fixed the origin of sound in carbon nanotubes in liquid
2013, managed shaping of Reside bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes